InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il18r1

Summary

InnateDB Protein

IDBP-265377.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il18r1

Protein Name

interleukin 18 receptor 1

Synonyms

Il18ralpha; Il1rrp;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103679

InnateDB Gene

IDBG-148535 (Il18r1)

Protein Structure

UniProt Annotation

Function

Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042008	interleukin-18 receptor activity

Biological Process

GO:0007165	signal transduction
GO:0030101	natural killer cell activation
GO:0032729	positive regulation of interferon-gamma production
GO:0035655	interleukin-18-mediated signaling pathway
GO:0042346	positive regulation of NF-kappaB import into nucleus
GO:0045063	T-helper 1 cell differentiation

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:105383

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013151 Immunoglobulin

PFAM

PF01582
PF13676
PF00047

PRINTS

PIRSF

SMART

SM00255
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61098