Homo sapiens Protein: DNMT1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Protein | IDBP-26539.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | DNMT1 | ||||||||||||||||||||||||||||
Protein Name | DNA (cytosine-5-)-methyltransferase 1 | ||||||||||||||||||||||||||||
Synonyms | ADCADN; AIM; CXXC9; DNMT; HSN1E; MCMT; | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000352516 | ||||||||||||||||||||||||||||
InnateDB Gene | IDBG-26537 (DNMT1) | ||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||
Function | Methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. {ECO:0000269PubMed:16357870, ECO:0000269PubMed:18413740, ECO:0000269PubMed:18754681}. | ||||||||||||||||||||||||||||
Subcellular Localization | Nucleus {ECO:0000269PubMed:12145218}. | ||||||||||||||||||||||||||||
Disease Associations | Neuropathy, hereditary sensory, 1E (HSN1E) [MIM:614116]: A neurodegenerative disorder characterized by adult onset of progressive peripheral sensory loss associated with progressive hearing impairment and early-onset dementia. {ECO:0000269PubMed:21532572}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cerebellar ataxia, deafness, and narcolepsy, autosomal dominant (ADCADN) [MIM:604121]: An autosomal dominant neurologic disorder characterized by adult onset of progressive cerebellar ataxia, narcolepsy, cataplexy, sensorineural deafness, and dementia. More variable features include optic atrophy, sensory neuropathy, psychosis, and depression. {ECO:0000269PubMed:22328086}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||||||||
Tissue Specificity | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. {ECO:0000269PubMed:10325416}. | ||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||
InterPro |
IPR001025
Bromo adjacent homology (BAH) domain IPR001525 C-5 cytosine methyltransferase IPR002857 Zinc finger, CXXC-type IPR010506 DMAP1-binding IPR017198 DNA (cytosine-5)-methyltransferase 1, eukaryote IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domain IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like |
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PFAM |
PF01426
PF00145 PF02008 PF06464 PF12047 |
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PRINTS |
PR00105
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PIRSF |
PIRSF037404
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SMART |
SM00439
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TIGRFAMs | |||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | P26358 | ||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P26358 | ||||||||||||||||||||||||||||
TrEMBL | K7ELB1 | ||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 1786 | ||||||||||||||||||||||||||||
UniGene | Hs.202672 | ||||||||||||||||||||||||||||
RefSeq | NP_001124295 | ||||||||||||||||||||||||||||
HUGO | HGNC:2976 | ||||||||||||||||||||||||||||
OMIM | 126375 | ||||||||||||||||||||||||||||
CCDS | CCDS45958 | ||||||||||||||||||||||||||||
HPRD | 00532 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AC010077 AC011511 AC020931 AF180682 AH008119 AK122759 BC092517 BC126227 BC144093 X63692 | ||||||||||||||||||||||||||||
GenPept | AAD51619 AAD54507 AAF23609 AAH92517 AAI26228 AAI44094 BAG53712 CAA45219 | ||||||||||||||||||||||||||||