Version 5.4
Mus musculus Protein: Msi2
Summary
InnateDB Protein IDBP-265665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msi2
Protein Name Musashi homolog 2 (Drosophila)
Synonyms 1700105C15Rik; AI451722; AI563628; AW489193; Msi2h;
Species Mus musculus
Ensembl Protein ENSMUSP00000103542
InnateDB Gene IDBG-207963 (Msi2)
Protein Structure
UniProt Annotation
Function RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system. {ECO:0000269PubMed:11588182, ECO:0000269PubMed:12407178}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11588182}. Note=Associated with polysomes.
Disease Associations
Tissue Specificity Ubiquitous. Expressed in proliferating neural precursor cells. {ECO:0000269PubMed:11588182, ECO:0000269PubMed:12923295}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003727 single-stranded RNA binding
GO:0008266 poly(U) RNA binding
Biological Process
GO:0048864 stem cell development
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
Protein Structure and Domains
PDB ID MGI:1923876
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920Q6
PhosphoSite PhosphoSite-Q920Q6
TrEMBL Q2M2Q8
UniProt Splice Variant
Entrez Gene 76626
UniGene Mm.474737
RefSeq XP_006534503
MGI ID
MGI Symbol Msi2
OMIM
CCDS
HPRD
IMGT
EMBL AB056102 AB056103 AK049637 AK049688 AK051269 AL645601 AL732539 BC111809 BK001483 BX572644 BX664717 CR405681 FP929013
GenPept AAI11810 BAB69484 BAB69485 BAC33851 BAC33873 BAC34584 DAA01567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca