Version 5.4
Mus musculus Protein: Akap1
Summary
InnateDB Protein IDBP-265677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akap1
Protein Name A kinase (PRKA) anchor protein 1
Synonyms Akap; AKAP121; AKAP84; C76494; C81186; DAKAP1; S-AKAP84;
Species Mus musculus
Ensembl Protein ENSMUSP00000103537
InnateDB Gene IDBG-208001 (Akap1)
Protein Structure
UniProt Annotation
Function Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A. Anchors them to the cytoplasmic face of the mitochondrial outer membrane or allows them to reside in the endoplasmic reticulum. Does not contain the classic KDEL endoplasmic reticulum-targeting sequence. This explains how it is able to switch its localization, either being in the endoplasmic reticulum or in the mitochondria depending on which N-terminal part begins the isoform. The longest N-terminal part only present in isoform 2 and isoform 4 acts as a suppressor of mitochondrial targeting and as an activator of recessive endoplasmic reticulum targeting motif.
Subcellular Localization Isoform 2: Endoplasmic reticulum.Isoform 4: Endoplasmic reticulum.Isoform 1: Mitochondrion outer membrane.Isoform 3: Mitochondrion outer membrane.Isoform 5: Mitochondrion outer membrane.Isoform 6: Mitochondrion outer membrane.
Disease Associations
Tissue Specificity Highest expression in testis, heart, liver, skeletal muscle, intestine and kidney, followed by brain and lung. No expression in spleen. Isoform 1/D-AKAP1A is expressed predominantly in testis whereas isoform 4/D-AKAP1D is expressed primarily in liver.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:104729
InterPro IPR002999 Tudor domain
IPR004087 K Homology domain
IPR004088 K Homology domain, type 1
PFAM PF00567
PF00013
PF13014
PRINTS
PIRSF
SMART SM00333
SM00322
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O08715
PhosphoSite PhosphoSite-O08715
TrEMBL
UniProt Splice Variant
Entrez Gene 11640
UniGene Mm.465395
RefSeq
MGI ID
MGI Symbol Akap1
OMIM
CCDS
HPRD
IMGT
EMBL AL596180 U84389 U95145 U95146
GenPept AAB53740 AAB53741 AAC27100 CAI24699

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca