InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nup62

Summary

InnateDB Protein

IDBP-265710.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nup62

Protein Name

nucleoporin 62

Synonyms

AA589433; AI426861; AI790512; AU045898; D7Ertd649e; Nupc1; p62;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103523

InnateDB Gene

IDBG-179750 (Nup62)

Protein Structure

UniProt Annotation

Function

Essential component of the nuclear pore complex. The N- terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nuclear pore complex. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 46 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	46 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore
GO:0030159	receptor signaling complex scaffold activity
GO:0042169	SH2 domain binding
GO:0043130	ubiquitin binding
GO:0046966	thyroid hormone receptor binding
GO:0051425	PTB domain binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007166	cell surface receptor signaling pathway
GO:0007569	cell aging
GO:0008219	cell death
GO:0008285	negative regulation of cell proliferation
GO:0015031	protein transport
GO:0016477	cell migration
GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043069	negative regulation of programmed cell death
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043407	negative regulation of MAP kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051028	mRNA transport