Version 5.4
Mus musculus Protein: Tmem8b
Summary
InnateDB Protein IDBP-265766.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmem8b
Protein Name transmembrane protein 8B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103496
InnateDB Gene IDBG-265760 (Tmem8b)
Protein Structure
UniProt Annotation
Function May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Also detected in mitochondrion and endoplasmic reticulum. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007160 cell-matrix adhesion
GO:0040008 regulation of growth
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2441680
InterPro IPR021910 Protein of unknown function DUF3522
PFAM PF12036
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt B1AWJ5
PhosphoSite PhosphoSite-B1AWJ5
TrEMBL
UniProt Splice Variant
Entrez Gene 242409
UniGene Mm.171489
RefSeq XP_006537974
MGI ID
MGI Symbol Tmem8b
OMIM
CCDS CCDS51168
HPRD
IMGT
EMBL AL732626 BC147569 BC147574 BC151067 BC151070
GenPept AAI47570 AAI47575 AAI51068 AAI51071 CAM17054

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca