Version 5.4
Mus musculus Protein: Trim59
Summary
InnateDB Protein IDBP-265918.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trim59
Protein Name tripartite motif-containing 59
Synonyms 2310035M22Rik; 2700022F13Rik; Mrf1; TSBF1;
Species Mus musculus
Ensembl Protein ENSMUSP00000103432
InnateDB Gene IDBG-151277 (Trim59)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response
GO:0046597 negative regulation of viral entry into host cell
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1914199
InterPro IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR018957 Zinc finger, C3HC4 RING-type
PFAM PF00643
PF13639
PF14634
PF00097
PRINTS
PIRSF
SMART SM00336
SM00184
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q922Y2
PhosphoSite PhosphoSite-
TrEMBL D3Z1L3
UniProt Splice Variant
Entrez Gene 66949
UniGene Mm.490341
RefSeq NP_080139
MGI ID
MGI Symbol Trim59
OMIM
CCDS CCDS17402
HPRD
IMGT
EMBL AC122876 AK009637 AK012269 AK016642 BC006700 BC025430
GenPept AAH06700 AAH25430 BAB26408 BAB28131 BAB30354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca