Version 5.4
Mus musculus Protein: Tmod1
Summary
InnateDB Protein IDBP-265957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmod1
Protein Name tropomodulin 1
Synonyms E-Tmod; Tmod;
Species Mus musculus
Ensembl Protein ENSMUSP00000103402
InnateDB Gene IDBG-144699 (Tmod1)
Protein Structure
UniProt Annotation
Function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity Highly expressed in the erythrocyte, heart and skeletal muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
GO:0006936 muscle contraction
GO:0008344 adult locomotory behavior
GO:0030239 myofibril assembly
Cellular Component
GO:0005856 cytoskeleton
GO:0008180 COP9 signalosome
GO:0016020 membrane
GO:0030016 myofibril
GO:0030863 cortical cytoskeleton
Protein Structure and Domains
PDB ID MGI:98775
InterPro IPR004934 Tropomodulin
PFAM PF03250
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49813
PhosphoSite PhosphoSite-P49813
TrEMBL G3UYG4
UniProt Splice Variant
Entrez Gene 21916
UniGene
RefSeq NP_068683
MGI ID
MGI Symbol Tmod1
OMIM
CCDS CCDS18143
HPRD
IMGT
EMBL AF287738 AF287739 AF287740 AF287741 AF287742 AF287743 AF287744 AF287745 AF287746 AL732615 BC106849 BC106850 CH466565 S76831
GenPept AAB33388 AAF91487 AAI06850 AAI06851 CAM17028 EDL02383

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca