Version 5.4
Mus musculus Protein: Hemgn
Summary
InnateDB Protein IDBP-265978.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hemgn
Protein Name hemogen
Synonyms 4921524M03Rik; AI317176; EDAG; Hgn; mNDR;
Species Mus musculus
Ensembl Protein ENSMUSP00000103393
InnateDB Gene IDBG-145207 (Hemgn)
Protein Structure
UniProt Annotation
Function Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11404085}.
Disease Associations
Tissue Specificity Expressed in hematopoietic precursor cells. Highly expressed in bone marrow, the red pulp of the spleen and round spermatids. Weakly expressed in peripheral blood cells. {ECO:0000269PubMed:11404085, ECO:0000269PubMed:14648837}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007275 multicellular organismal development
GO:0030154 cell differentiation
GO:0045667 regulation of osteoblast differentiation
Cellular Component
GO:0005654 nucleoplasm
Protein Structure and Domains
PDB ID MGI:2136910
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ERZ0
PhosphoSite PhosphoSite-Q9ERZ0
TrEMBL
UniProt Splice Variant
Entrez Gene 93966
UniGene Mm.473136
RefSeq NP_444379
MGI ID
MGI Symbol Hemgn
OMIM
CCDS CCDS18150
HPRD
IMGT
EMBL AF269248 AK006588 AK077692 AK156536 AK171890 AL683884 AY699986 BC050798
GenPept AAG33367 AAH50798 AAT94243 BAC25148 BAC36959 BAE33747 BAE42722 CAM13788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca