Version 5.4
Mus musculus Protein: Tbc1d2
Summary
InnateDB Protein IDBP-266002.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tbc1d2
Protein Name TBC1 domain family, member 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103379
InnateDB Gene IDBG-145611 (Tbc1d2)
Protein Structure
UniProt Annotation
Function Acts as GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005097 Rab GTPase activator activity
GO:0045296 cadherin binding
Biological Process
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:2652885
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt B1AVH7
PhosphoSite PhosphoSite-B1AVH7
TrEMBL
UniProt Splice Variant
Entrez Gene 381605
UniGene Mm.331595
RefSeq
MGI ID
MGI Symbol Tbc1d2
OMIM
CCDS
HPRD
IMGT
EMBL AK041359 AK148254 AL683884 BX571848 BX682536
GenPept BAC30918 BAE28440 CAM13787 CAM17021 CAM17022 CAM27677 CAM27678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca