InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgfbr1

Summary

InnateDB Protein

IDBP-266057.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Tgfbr1

Protein Name

transforming growth factor, beta receptor I

Synonyms

Alk-5; ALK5; AU017191; TbetaR-I; TbetaRI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103353

InnateDB Gene

IDBG-146050 (Tgfbr1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004675	transmembrane receptor protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005024	transforming growth factor beta-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050431	transforming growth factor beta binding

Biological Process

GO:0001501	skeletal system development
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001822	kidney development
GO:0001824	blastocyst development
GO:0001937	negative regulation of endothelial cell proliferation
GO:0002088	lens development in camera-type eye
GO:0006468	protein phosphorylation
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007507	heart development
GO:0008354	germ cell migration
GO:0009791	post-embryonic development
GO:0009952	anterior/posterior pattern specification
GO:0010468	regulation of gene expression
GO:0023014	signal transduction by phosphorylation
GO:0030199	collagen fibril organization
GO:0043066	negative regulation of apoptotic process
GO:0043393	regulation of protein binding
GO:0043542	endothelial cell migration
GO:0048538	thymus development
GO:0048663	neuron fate commitment
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048705	skeletal system morphogenesis
GO:0048844	artery morphogenesis
GO:0051491	positive regulation of filopodium assembly
GO:0060017	parathyroid gland development
GO:0060021	palate development
GO:0060037	pharyngeal system development

Cellular Component

GO:0005901	caveola
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

MGI:98728

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003605 TGF beta receptor, GS motif
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF08515

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00467
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9D5H8

UniProt Splice Variant

Entrez Gene

21812

UniGene

Mm.452145

RefSeq

MGI ID

MGI Symbol

Tgfbr1

OMIM

CCDS

HPRD

IMGT

EMBL

AK007125 AK015337 AL772150 AL772232

GenPept

BAB24865 BAB29802