InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gngt2

Summary

InnateDB Protein

IDBP-266089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gngt2

Protein Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2

Synonyms

AV096488;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103339

InnateDB Gene

IDBG-209692 (Gngt2)

Protein Structure

UniProt Annotation

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.

Subcellular Localization

Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity

Biological Process

GO:0006184	GTP catabolic process
GO:0007186	G-protein coupled receptor signaling pathway

Cellular Component

GO:0005834

heterotrimeric G-protein complex

Protein Structure and Domains

PDB ID

MGI:893584

InterPro

IPR001770 G-protein, gamma subunit
IPR015898 G-protein gamma-like domain

PFAM

PF00631

PRINTS

PR00321

PIRSF

SMART

SM00224

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61017

PhosphoSite

PhosphoSite-

TrEMBL

A2A614

UniProt Splice Variant

Entrez Gene

14710

UniGene

RefSeq

NP_001271322

MGI ID

MGI Symbol

Gngt2

OMIM

CCDS

CCDS25284

HPRD

IMGT

EMBL

AK010554 AL593858 CH466556 U38500

GenPept

AAB01731 BAB27023 CAM15514 EDL15997 EDL15998