Version 5.4
Mus musculus Protein: Ttll6
Summary
InnateDB Protein IDBP-266156.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ttll6
Protein Name tubulin tyrosine ligase-like family, member 6
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000103307
InnateDB Gene IDBG-209841 (Ttll6)
Protein Structure
UniProt Annotation
Function Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. {ECO:0000269PubMed:17499049, ECO:0000269PubMed:21074048}.
Subcellular Localization Cell projection, cilium {ECO:0000269PubMed:17499049}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269PubMed:17499049}. Note=CEP41 is required for its transport between the basal body and the cilium.
Disease Associations
Tissue Specificity Widely expressed with highest levels in testis. {ECO:0000269PubMed:17499049}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015631 tubulin binding
GO:0016874 ligase activity
Biological Process
GO:0001578 microtubule bundle formation
GO:0003353 positive regulation of cilium movement
GO:0006464 cellular protein modification process
GO:0018095 protein polyglutamylation
GO:0051013 microtubule severing
Cellular Component
GO:0005737 cytoplasm
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID MGI:2683461
InterPro IPR004344 Tubulin-tyrosine ligase/Tubulin polyglutamylase
PFAM PF03133
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A4Q9E8
PhosphoSite PhosphoSite-A4Q9E8
TrEMBL
UniProt Splice Variant
Entrez Gene 237930
UniGene Mm.249912
RefSeq
MGI ID
MGI Symbol Ttll6
OMIM
CCDS
HPRD
IMGT
EMBL AK077033 AK145771 AL603682 AM690749 BC132203 BC138058 BC145131
GenPept AAI32204 AAI38059 AAI45132 BAC36577 BAE26641 CAM18273 CAM18274 CAM84326

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca