InnateDB Protein
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IDBP-26621.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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COLEC11
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Protein Name
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collectin sub-family member 11
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000371494
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InnateDB Gene
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IDBG-26615 (COLEC11)
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Protein Structure
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Function |
Lectin that binds to various sugars including fucose and mannose. Has a higher affinity for fucose compared to mannose. Does not bind to glucose, N-acetylglucosamine and N- acetylgalactosamine. Also binds lipopolysaccharides (LPS). Involved in fundamental development serving as a guidance cue for neural crest cell migration (By similarity). {ECO:0000250}.
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Subcellular Localization |
Secreted {ECO:0000305}.
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Disease Associations |
3MC syndrome 2 (3MC2) [MIM:265050]: A disorder characterized by facial dysmorphism that includes hypertelorism, blepharophimosis, blepharoptosis and highly arched eyebrows, cleft lip and/or palate, craniosynostosis, learning disability and genital, limb and vesicorenal anomalies. The term 3MC syndrome includes Carnevale, Mingarelli, Malpuech, and Michels syndromes. {ECO:0000269PubMed:21258343}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:17179669}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001304
C-type lectin
IPR008160
Collagen triple helix repeat
IPR016187
C-type lectin fold
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PFAM |
PF00059
PF01391
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PRINTS |
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PIRSF |
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SMART |
SM00034
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BWP8
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PhosphoSite |
PhosphoSite-Q9BWP8
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
78989
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UniGene |
Hs.32603
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RefSeq |
NP_001242913
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HUGO |
HGNC:17213
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OMIM |
612502
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CCDS |
CCDS58690
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HPRD |
10847
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IMGT |
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EMBL |
AB119525
AB119650
AB119651
AB119652
AB119684
AB119685
AB119686
AB119687
AC010907
AK303824
AK313840
AY358439
BC000078
BC009951
CH471053
CR936641
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GenPept |
AAH00078
AAH09951
AAQ88805
AAY24235
BAF43301
BAF43302
BAF43303
BAF43304
BAF79604
BAF79605
BAF79606
BAF79607
BAG36572
BAG64772
CAI56781
EAX01053
EAX01054
EAX01055
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