InnateDB Protein
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IDBP-266570.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Msl1
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Protein Name
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male-specific lethal 1 homolog (Drosophila)
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Synonyms
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2810017F12Rik; 4121402D02Rik; 4930463F05Rik; AA682082; Msl-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103109
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InnateDB Gene
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IDBG-210769 (Msl1)
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Protein Structure
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Function |
Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at 'Lys-17' which is implicated in the formation of higher-order chromatin. structure (By similarity). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub). This modification in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1. In the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation. {ECO:0000250, ECO:0000269PubMed:21217699}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:16119455}.
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Disease Associations |
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Tissue Specificity |
Expressed in testis and several other tissues. {ECO:0000269PubMed:16119455}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1921276
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q6PDM1
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PhosphoSite |
PhosphoSite-Q6PDM1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
74026
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UniGene |
Mm.409986
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RefSeq |
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MGI ID |
2Y0N
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MGI Symbol |
Msl1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK014463
AK015496
AK053719
AK161412
AL590963
BC043039
BC055715
BC058629
DQ387855
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GenPept |
AAH43039
AAH55715
AAH58629
ABD46887
BAB29369
BAB29868
BAC35489
BAE36380
CAM46183
CAM46184
CAM46185
CAM46186
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