InnateDB Protein
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IDBP-266680.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rgs3
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Protein Name
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regulator of G-protein signaling 3
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Synonyms
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4930506N09Rik; C2pa; C2PA-RGS3; PDZ-RGS3; RGS3S;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103043
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InnateDB Gene
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IDBG-153650 (Rgs3)
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Protein Structure
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Function |
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G- protein-mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269PubMed:11301003, ECO:0000269PubMed:12210723}.
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Subcellular Localization |
Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=The long isoforms are cytoplasmic.Isoform 3: Nucleus. Note=Isoform 3 and probably also isoform 4 are nuclear.Isoform 4: Nucleus. Note=Isoform 3 and probably also isoform 4 are nuclear.
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Disease Associations |
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Tissue Specificity |
Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newborn mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed. {ECO:0000269PubMed:11034339}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
GO:0007186
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G-protein coupled receptor signaling pathway
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GO:0038032
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termination of G-protein coupled receptor signaling pathway
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GO:0043547
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positive regulation of GTPase activity
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Cellular Component |
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PDB ID |
MGI:1354734
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InterPro |
IPR000342
Regulator of G protein signalling domain
IPR016137
Regulator of G protein signalling superfamily
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PFAM |
PF00615
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PRINTS |
PR01301
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PIRSF |
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SMART |
SM00315
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TIGRFAMs |
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Modification |
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SwissProt |
Q9DC04
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PhosphoSite |
PhosphoSite-Q9DC04
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TrEMBL |
Q3TAS0
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UniProt Splice Variant |
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Entrez Gene |
50780
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UniGene |
Mm.413144
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RefSeq |
XP_006538128
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MGI ID |
1WHD
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MGI Symbol |
Rgs3
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF215669
AF215670
AF319519
AF350047
AJ250999
AK004648
AK028445
AK171666
AL672272
BC033449
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GenPept |
AAF34626
AAF34627
AAH33449
AAK38878
AAL37173
BAB23439
BAC25954
BAE42598
CAB66146
CAI25817
CAI25819
CAI25820
CAI25824
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