InnateDB Protein
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IDBP-266709.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Aen
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Protein Name
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apoptosis enhancing nuclease
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Synonyms
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2700083B06Rik; Isg20l1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103046
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InnateDB Gene
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IDBG-193491 (Aen)
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Protein Structure
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Function |
Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0010212
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response to ionizing radiation
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GO:0042771
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intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
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GO:0090305
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nucleic acid phosphodiester bond hydrolysis
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Cellular Component |
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PDB ID |
MGI:1915298
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InterPro |
IPR006055
Exonuclease
IPR012337
Ribonuclease H-like domain
IPR013520
Exonuclease, RNase T/DNA polymerase III
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PFAM |
PF00929
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PRINTS |
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PIRSF |
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SMART |
SM00479
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CZI9
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PhosphoSite |
PhosphoSite-Q9CZI9
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TrEMBL |
D3Z516
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UniProt Splice Variant |
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Entrez Gene |
68048
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UniGene |
Mm.482669
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RefSeq |
XP_006541200
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MGI ID |
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MGI Symbol |
Aen
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OMIM |
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CCDS |
CCDS39988
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HPRD |
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IMGT |
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EMBL |
AC138376
AK012555
AK031972
AK090056
AK165708
AK166806
AK167042
AK167658
BC022614
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GenPept |
AAH22614
BAB28314
BAC27632
BAC41071
BAE38348
BAE39034
BAE39210
BAE39708
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