Version 5.4
Mus musculus Protein: Krt15
Summary
InnateDB Protein IDBP-266731.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Krt15
Protein Name keratin 15
Synonyms AI528832; K15; Krt1-15;
Species Mus musculus
Ensembl Protein ENSMUSP00000103034
InnateDB Gene IDBG-211256 (Krt15)
Protein Structure
UniProt Annotation
Function In the absence of KRT14, makes a bona fide, but ultrastructurally distinct keratin filament network with KRT5. {ECO:0000269PubMed:10623468, ECO:0000269PubMed:7539810}.
Subcellular Localization
Disease Associations
Tissue Specificity Expressed strongly in the basal cell layer at the tips of rete-like prominences (RLPs) of adult dorsal tongue, outer root sheath (ORS) of hair follicle and skin epidermis (at protein level). {ECO:0000269PubMed:10623468, ECO:0000269PubMed:14506658}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 52 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 52 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0097110 scaffold protein binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005882 intermediate filament
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:96689
InterPro IPR001664 Intermediate filament protein
IPR002957 Keratin, type I
IPR009053 Prefoldin
PFAM PF00038
PRINTS PR01248
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61414
PhosphoSite PhosphoSite-Q61414
TrEMBL B1AQ77
UniProt Splice Variant
Entrez Gene 16665
UniGene Mm.440010
RefSeq NP_032495
MGI ID
MGI Symbol Krt15
OMIM
CCDS CCDS25410
HPRD
IMGT
EMBL AL590873 BC057934 CH466662 D16313
GenPept AAH57934 BAA03821 EDL02576

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca