InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Anpep

Summary

InnateDB Protein

IDBP-266781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anpep

Protein Name

alanyl (membrane) aminopeptidase

Synonyms

AP-M; AP-N; Apn; Cd13; P150;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103015

InnateDB Gene

IDBG-194391 (Anpep)

Protein Structure

UniProt Annotation

Function

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May have a role in angiogenesis (By similarity). Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells. {ECO:0000250, ECO:0000269PubMed:8103749}.

Subcellular Localization

Membrane; Single-pass type II membrane protein.

Disease Associations

Tissue Specificity

Highly expressed in intestinal tract and kidney, present in liver, lymph node, spleen, and brain. Found as well in monocytes, macrophages, dendritic cells, veiled cells and B-cells but not on T-cells and thymocytes. {ECO:0000269PubMed:8805662}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0001525	angiogenesis
GO:0006508	proteolysis
GO:0030154	cell differentiation

Cellular Component

GO:0005615	extracellular space
GO:0005765	lysosomal membrane
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment
GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome