InnateDB Protein
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IDBP-266783.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Idh2
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Protein Name
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isocitrate dehydrogenase 2 (NADP+), mitochondrial
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103007
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InnateDB Gene
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IDBG-194560 (Idh2)
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Protein Structure
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Function |
Plays a role in intermediary metabolism and energy production. It may tightly associate or interact with the pyruvate dehydrogenase complex.
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Subcellular Localization |
Mitochondrion.
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Disease Associations |
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Tissue Specificity |
Heart > kidney >> other tissues. {ECO:0000269PubMed:11278619}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
|
Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0000287
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magnesium ion binding
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GO:0004450
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isocitrate dehydrogenase (NADP+) activity
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GO:0016616
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oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
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GO:0051287
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NAD binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:96414
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InterPro |
IPR004790
Isocitrate dehydrogenase NADP-dependent
IPR024084
Isopropylmalate dehydrogenase-like domain
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PFAM |
PF00180
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PRINTS |
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PIRSF |
PIRSF000108
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P54071
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PhosphoSite |
PhosphoSite-P54071
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
269951
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UniGene |
Mm.452336
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RefSeq |
NP_766599
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MGI ID |
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MGI Symbol |
Idh2
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OMIM |
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CCDS |
CCDS39994
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HPRD |
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IMGT |
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EMBL |
AF212319
AK088110
AK145753
AK161640
AK169395
BC060030
U51167
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GenPept |
AAC52473
AAG43538
AAH60030
BAC40149
BAE26628
BAE36505
BAE41142
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