Version 5.4
Mus musculus Protein: Rfx5
Summary
InnateDB Protein IDBP-267061.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rfx5
Protein Name regulatory factor X, 5 (influences HLA class II expression)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102876
InnateDB Gene IDBG-171037 (Rfx5)
Protein Structure
UniProt Annotation
Function Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. {ECO:0000269PubMed:10779326}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00858, ECO:0000269PubMed:10779326}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1858421
InterPro IPR003150 DNA-binding RFX-type winged-helix domain
PFAM PF02257
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JL61
PhosphoSite PhosphoSite-Q9JL61
TrEMBL Q0P5W9
UniProt Splice Variant
Entrez Gene 53970
UniGene Mm.24308
RefSeq
MGI ID
MGI Symbol Rfx5
OMIM
CCDS CCDS17598
HPRD
IMGT
EMBL AC087062 AF209854 AK156195 BC051965 BC118948 BC118949 CH466620
GenPept AAF68260 AAH51965 AAI18949 AAI18950 BAE33620 EDL38756

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca