InnateDB Protein
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IDBP-267105.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Pip5k1a
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Protein Name
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phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
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Synonyms
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PI4P5K-I[a]; PIP5K1-alpha; PIP5KIalpha; Pipk5a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102855
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InnateDB Gene
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IDBG-171304 (Pip5k1a)
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Protein Structure
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Function |
Catalyzes the phosphorylation of phosphatidylinositol 4- phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs. {ECO:0000269PubMed:10679324, ECO:0000269PubMed:18772378, ECO:0000269PubMed:19153220, ECO:0000269PubMed:20622009, ECO:0000269PubMed:8798574}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:20622009}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:20622009}. Cell projection, ruffle {ECO:0000250}. Note=Colocalizes with RAC1 at actin-rich membrane ruffles. Localizes to nuclear speckles and associates with TUT1 to regulate polyadenylation of selected mRNAs. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highest expression in brain. Also detected in skeletal muscle, testis, brain and lung. {ECO:0000269PubMed:20622009, ECO:0000269PubMed:8798574}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
6 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:107929
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InterPro |
IPR002498
Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034
Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup
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PFAM |
PF01504
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PRINTS |
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PIRSF |
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SMART |
SM00330
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TIGRFAMs |
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Modification |
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SwissProt |
P70182
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PhosphoSite |
PhosphoSite-P70182
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18720
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UniGene |
Mm.402240
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RefSeq |
NP_032873
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MGI ID |
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MGI Symbol |
Pip5k1a
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OMIM |
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CCDS |
CCDS38542
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HPRD |
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IMGT |
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EMBL |
AC087062
AC131769
AK150898
AK151984
AK158062
BC003763
BC031774
D86177
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GenPept |
AAH03763
AAH31774
BAA13031
BAE29943
BAE30850
BAE34344
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