InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tmod4

Summary

InnateDB Protein

IDBP-267123.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tmod4

Protein Name

tropomodulin 4

Synonyms

MTMOD; Sk-Tmod;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102846

InnateDB Gene

IDBG-171457 (Tmod4)

Protein Structure

UniProt Annotation

Function

Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005523	tropomyosin binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005856	cytoskeleton
GO:0005865	striated muscle thin filament

Protein Structure and Domains

PDB ID

MGI:1355285

InterPro

IPR004934 Tropomodulin

PFAM

PF03250

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLH8

PhosphoSite

PhosphoSite-

TrEMBL

Q3UN19

UniProt Splice Variant

Entrez Gene

50874

UniGene

Mm.71935

RefSeq

MGI ID

MGI Symbol

Tmod4

OMIM

CCDS

CCDS17601

HPRD

IMGT

EMBL

AC131769 AF177174 AK144408 AK144535 BC068020 CH466620

GenPept

AAF31673 AAH68020 BAE25875 BAE25929 EDL38774