InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FABP4

Summary

InnateDB Protein

IDBP-26717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FABP4

Protein Name

fatty acid binding protein 4, adipocyte

Synonyms

A-FABP; AFABP; ALBP; aP2; HEL-S-104;

Species

Homo sapiens

Ensembl Protein

ENSP00000256104

InnateDB Gene

IDBG-26715 (FABP4)

Protein Structure

UniProt Annotation

Function

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005504	fatty acid binding

Biological Process

GO:0001816	cytokine production
GO:0006469	negative regulation of protein kinase activity
GO:0006810	transport
GO:0019433	triglyceride catabolic process
GO:0042632	cholesterol homeostasis
GO:0044281	small molecule metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050729	positive regulation of inflammatory response
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0071285	cellular response to lithium ion