InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dlg2

Summary

InnateDB Protein

IDBP-267180.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlg2

Protein Name

discs, large homolog 2 (Drosophila)

Synonyms

A330103J02Rik; B230218P12Rik; B330007M19Rik; Dlgh2; Gm1197; PSD93;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102814

InnateDB Gene

IDBG-198905 (Dlg2)

Protein Structure

UniProt Annotation

Function

Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses. {ECO:0000269PubMed:12890763}.

Subcellular Localization

Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Concentrated in soma and postsynaptic density of a subset of neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain. Highest levels of isoform 1 in cortex, olfactory bulb, thalamus, hypothalamus, striatum and hippocampus. Highest level of isoform 2 in olfactory bulb. Reduced levels in cortex and hippocampus. Highest level of isoform 4 in spinal cord. Low levels of isoform 4, isoform 6, and isoform 7 in superior cervical ganglion. {ECO:0000269PubMed:12890763, ECO:0000269PubMed:15304517}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007268	synaptic transmission
GO:0010923	negative regulation of phosphatase activity
GO:0019233	sensory perception of pain

Cellular Component

GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0044224	juxtaparanode region of axon
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1344351

InterPro

IPR001452 SH3 domain
IPR001478 PDZ domain
IPR008144 Guanylate kinase-like
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR011511 Variant SH3 domain
IPR016313 Disks large 1
IPR019583 PDZ-associated domain of NMDA receptors
IPR019590 Membrane-associated guanylate kinase (MAGUK), PEST domain, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM