InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tenm4

Summary

InnateDB Protein

IDBP-267243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tenm4

Protein Name

odd Oz/ten-m homolog 4 (Drosophila)

Synonyms

Doc4; ELM2; l(7)-3Rn; l7Rn3; mKIAA1302; Odz4; R75022; Ten-m4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102780

InnateDB Gene

IDBG-199369 (Tenm4)

Protein Structure

UniProt Annotation

Function

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small- diameter axons in the central nervous system (CNS). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer. {ECO:0000269PubMed:15489520, ECO:0000269PubMed:22915103}.

Subcellular Localization

Membrane {ECO:0000305PubMed:22915103}; Single-pass membrane protein {ECO:0000305PubMed:22915103}. Nucleus {ECO:0000269PubMed:22915103}. Cytoplasm {ECO:0000269PubMed:22915103}. Cell projection {ECO:0000269PubMed:22915103}.

Disease Associations

Tissue Specificity

Expressed in brain and spinal cord (at protein level). Expressed in neurons and oligodendrocytes of the spinal cord. Expressed weakly in kidney, lung and spleen. Expressed in the cortex, CA1, CA2 and CA3 of the hippocampus. Expressed in the white matter, Purkinje cells and molecular layer of the cerebellum. {ECO:0000269PubMed:12915301, ECO:0000269PubMed:15489520, ECO:0000269PubMed:22915103}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001702	gastrulation with mouth forming second
GO:0007165	signal transduction
GO:0031643	positive regulation of myelination
GO:0032289	central nervous system myelin formation
GO:0048666	neuron development
GO:0048714	positive regulation of oligodendrocyte differentiation
GO:0060038	cardiac muscle cell proliferation
GO:0060912	cardiac cell fate specification
GO:0097264	self proteolysis
GO:2000543	positive regulation of gastrulation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043005	neuron projection

Protein Structure and Domains

PDB ID

MGI:2447063

InterPro

IPR000742 Epidermal growth factor-like domain
IPR006530 YD repeat
IPR008969 Carboxypeptidase-like, regulatory domain
IPR009471 Teneurin intracellular, N-terminal
IPR013111 EGF-like domain, extracellular
IPR022385 Rhs repeat-associated core

PFAM

PF00008
PF05593
PF06484
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UHK6