Version 5.4
Mus musculus Protein: Cd300lg
Summary
InnateDB Protein IDBP-267257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd300lg
Protein Name CD300 antigen like family member G
Synonyms 2310016B05Rik; Clm9; D11Ertd736e;
Species Mus musculus
Ensembl Protein ENSMUSP00000102782
InnateDB Gene IDBG-212432 (Cd300lg)
Protein Structure
UniProt Annotation
Function Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte. {ECO:0000269PubMed:16754720, ECO:0000269PubMed:16876123}.
Subcellular Localization Apical cell membrane; Single-pass type I membrane protein. Basolateral cell membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single- pass type I membrane protein. Note=Exclusively localized on capillary endothelium. Transcytoses across the cytoplasm in the capillary endothelium.
Disease Associations
Tissue Specificity Expressed in monocyte cell lines. Expressed in certain types of endothelial and myeloid lineage cells. Expressed in mesenteric lymph nodes (LNs), spleen, thymus, lung, heart and kidney. Expressed in high endothelial venules (HEVs) in peripheral and mesenteric LNs (at protein level). Highly expressed in heart. Slightly expressed in spleen and thymus. Isoform 5 is expressed preferentially in heart. Isoform 1 is expressed predominantly in kidney and liver. {ECO:0000269PubMed:14662855, ECO:0000269PubMed:16754720, ECO:0000269PubMed:16876123}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0001791 IgM binding
GO:0005515 protein binding
Biological Process
GO:0002376 immune system process
GO:0002414 immunoglobulin transcytosis in epithelial cells
Cellular Component
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0032585 multivesicular body membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1289168
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1ERP8
PhosphoSite PhosphoSite-Q1ERP8
TrEMBL
UniProt Splice Variant
Entrez Gene 52685
UniGene Mm.266885
RefSeq NP_001154184
MGI ID
MGI Symbol Cd300lg
OMIM
CCDS CCDS48939
HPRD
IMGT
EMBL AB243063 AB243064 AB243065 AB243066 AK009375 AK138920 AK171982 AL591145 AY457055 BC116906 BC119315
GenPept AAI16907 AAI19316 AAR27946 BAB26251 BAE23817 BAE42759 BAE96046 BAE96047 BAE96048 BAE96049 CAM23248 CAM23249 CAM23250 CAM23251

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca