InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdkn2a

Summary

InnateDB Protein

IDBP-267341.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdkn2a

Protein Name

cyclin-dependent kinase inhibitor 2A

Synonyms

Arf; ARF-INK4a; INK4a-ARF; Ink4a/Arf; MTS1; p16; p16(INK4a); p16INK4a; p19; p19ARF; Pctr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102748

InnateDB Gene

IDBG-162905 (Cdkn2a)

Protein Structure

UniProt Annotation

Function

Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.

Experimentally validated
Total	77 [view]
Protein-Protein	65 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0055105	ubiquitin-protein transferase inhibitor activity

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000209	protein polyubiquitination
GO:0006355	regulation of transcription, DNA-templated
GO:0006364	rRNA processing
GO:0006915	apoptotic process
GO:0007050	cell cycle arrest
GO:0007568	aging
GO:0007569	cell aging
GO:0008544	epidermis development
GO:0009303	rRNA transcription
GO:0010468	regulation of gene expression
GO:0030308	negative regulation of cell growth
GO:0030889	negative regulation of B cell proliferation
GO:0031647	regulation of protein stability
GO:0033088	negative regulation of immature T cell proliferation in thymus
GO:0033600	negative regulation of mammary gland epithelial cell proliferation
GO:0035019	somatic stem cell maintenance
GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045087	innate immune response (InnateDB)
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045786	negative regulation of cell cycle
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046822	regulation of nucleocytoplasmic transport
GO:0048103	somatic stem cell division
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0060058	positive regulation of apoptotic process involved in mammary gland involution
GO:0070301	cellular response to hydrogen peroxide
GO:0070534	protein K63-linked ubiquitination