Version 5.4
Mus musculus Protein: Plekhb1
Summary
InnateDB Protein IDBP-267510.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Plekhb1
Protein Name pleckstrin homology domain containing, family B (evectins) member 1
Synonyms AI315628; evt-1; PHR1; Phret1;
Species Mus musculus
Ensembl Protein ENSMUSP00000102661
InnateDB Gene IDBG-201608 (Plekhb1)
Protein Structure
UniProt Annotation
Function Required for proper localization of retinogeniculate projections but not for eye-specific segregation. {ECO:0000269PubMed:19371781}.
Subcellular Localization Membrane {ECO:0000269PubMed:20301200}. Cytoplasm {ECO:0000269PubMed:20301200}. Note=Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. Localizes to the apical juxta-nuclear Golgi region of the cytoplasm.
Disease Associations
Tissue Specificity Highly expressed in retina and brain. In retina, abundantly expressed in photoreceptors. Isoform 4 is the predominant isoform expressed in mature olfactory receptor neurons and vestibular and cochlear hair cells. Also expressed in cells with possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ (at protein level). {ECO:0000269PubMed:10585447, ECO:0000269PubMed:15456885, ECO:0000269PubMed:20301200}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0007275 multicellular organismal development
GO:0045595 regulation of cell differentiation
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1351469
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QYE9
PhosphoSite PhosphoSite-Q9QYE9
TrEMBL Q3TP62
UniProt Splice Variant
Entrez Gene 27276
UniGene Mm.490749
RefSeq NP_001156659
MGI ID 2D9V
MGI Symbol Plekhb1
OMIM
CCDS CCDS52324
HPRD
IMGT
EMBL AC124531 AF000272 AF071000 AF071001 AF100613 AF101053 AK005102 AK158172 AK164683 BC024756 CH466531
GenPept AAD32952 AAF16676 AAF16683 AAF18571 AAF18933 AAH24756 BAB23819 BAE34392 BAE37875 EDL16469 EDL16471

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca