Version 5.4
Mus musculus Protein: Tomt
Summary
InnateDB Protein IDBP-267665.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tomt
Protein Name transmembrane O-methyltransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102582
InnateDB Gene IDBG-267661 (Tomt)
Protein Structure
UniProt Annotation
Function Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function. {ECO:0000250UniProtKB:P21964, ECO:0000269PubMed:18794526}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18953341}.
Disease Associations
Tissue Specificity Widely expressed with high levels in outer and inner hair cells of the cochlea and vestibule. {ECO:0000269PubMed:18794526, ECO:0000269PubMed:18953341}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008171 O-methyltransferase activity
GO:0016206 catechol O-methyltransferase activity
Biological Process
GO:0007605 sensory perception of sound
GO:0032259 methylation
GO:0042135 neurotransmitter catabolic process
GO:0042424 catecholamine catabolic process
GO:0060117 auditory receptor cell development
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:3769724
InterPro IPR002935 O-methyltransferase, family 3
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01596
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A1Y9I9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 791260
UniGene Mm.475469
RefSeq NP_001269017
MGI ID
MGI Symbol Tomt
OMIM
CCDS CCDS40044
HPRD
IMGT
EMBL DQ854743 EU627091
GenPept ABI37014 ACF40901

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca