Version 5.4
Mus musculus Protein: Stk33
Summary
InnateDB Protein IDBP-268137.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stk33
Protein Name serine/threonine kinase 33
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102356
InnateDB Gene IDBG-206113 (Stk33)
Protein Structure
UniProt Annotation
Function Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME. {ECO:0000269PubMed:18811945}.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:16176263}.
Disease Associations
Tissue Specificity Highly expressed in testis, particularly in cells from the spermatogenic epithelia. Significant expression is detected in lung epithelia, alveolar macrophages, horizontal cells in the retina and in embryonic organs such as heart, brain and spinal cord. Also expressed in pituitary gland, kidney, pancreas, trachea and thyroid gland. {ECO:0000269PubMed:16176263}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0046777 protein autophosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2152419
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q924X7
PhosphoSite PhosphoSite-Q924X7
TrEMBL D3YWA6
UniProt Splice Variant
Entrez Gene 117229
UniGene Mm.389950
RefSeq NP_473444
MGI ID
MGI Symbol Stk33
OMIM
CCDS CCDS52358
HPRD
IMGT
EMBL AC124457 AC147221 AC165143 AJ307671 AK014819 AM056057
GenPept CAC39171 CAJ20841

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca