InnateDB Protein
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IDBP-268312.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Usp47
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Protein Name
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ubiquitin specific peptidase 47
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Synonyms
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4930502N04Rik; A630020C16Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102264
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InnateDB Gene
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IDBG-206869 (Usp47)
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Protein Structure
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Function |
Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER) (By similarity). Acts as a regulator of cell growth and genome integrity. May also indirectly regulates CDC25A expression at a transcriptional level. {ECO:0000250, ECO:0000269PubMed:19966869}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
7 [view]
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Molecular Function |
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Biological Process |
GO:0006284
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base-excision repair
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0006974
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cellular response to DNA damage stimulus
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GO:0010972
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negative regulation of G2/M transition of mitotic cell cycle
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GO:0030307
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positive regulation of cell growth
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GO:0034644
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cellular response to UV
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GO:0035520
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monoubiquitinated protein deubiquitination
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GO:0042493
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response to drug
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GO:0043066
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negative regulation of apoptotic process
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GO:0043154
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negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:1902230
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negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
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Cellular Component |
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PDB ID |
MGI:1922246
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InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
IPR029071
Ubiquitin-related domain
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PFAM |
PF00443
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BY87
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PhosphoSite |
PhosphoSite-Q8BY87
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
74996
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UniGene |
Mm.16974
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RefSeq |
NP_796223
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MGI ID |
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MGI Symbol |
Usp47
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OMIM |
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CCDS |
CCDS40089
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HPRD |
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IMGT |
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EMBL |
AK030909
AK030963
AK041541
AK082114
AK087981
AK131138
BC012722
BC024117
BC089364
BC108425
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GenPept |
AAH12722
AAH24117
AAH89364
AAI08426
BAC27179
BAC27195
BAC30979
BAC38411
BAC40073
BAD21388
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