InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Amigo1

Summary

InnateDB Protein

IDBP-268318.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Amigo1

Protein Name

adhesion molecule with Ig like domain 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102270

InnateDB Gene

IDBG-186431 (Amigo1)

Protein Structure

UniProt Annotation

Function

Promotes growth and fasciculation of neurites from cultured hippocampal neurons. May be involved in fasciculation as well as myelination of developing neural axons. May have a role in regeneration as well as neural plasticity in the adult nervous system. May mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain (By similarity). {ECO:0000250UniProtKB:Q80ZD7}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:21983541}; Single-pass type I membrane protein {ECO:0000269PubMed:21983541}. Note=Associated with axons of neuronal cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

High levels in cerebellum, cerebrum, and retina. Low levels in liver, kidney, small intestine, spleen, lung and heart. {ECO:0000269PubMed:12629050}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007409	axonogenesis
GO:0007413	axonal fasciculation
GO:0042552	myelination
GO:0050772	positive regulation of axonogenesis