InnateDB Protein
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IDBP-268456.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Henmt1
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Protein Name
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RIKEN cDNA 4921515J06 gene
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Synonyms
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4921515J06Rik; Hen1; mHEN1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102196
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InnateDB Gene
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IDBG-188190 (Henmt1)
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Protein Structure
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Function |
Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000269PubMed:17652135, ECO:0000269PubMed:18029764}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Specifically expressed in testis. {ECO:0000269PubMed:17652135, ECO:0000269PubMed:18029764}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913965
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InterPro |
IPR029063
S-adenosyl-L-methionine-dependent methyltransferase-like
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CAE2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66715
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UniGene |
Mm.158124
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RefSeq |
NP_001072114
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MGI ID |
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MGI Symbol |
Henmt1
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OMIM |
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CCDS |
CCDS38602
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HPRD |
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IMGT |
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EMBL |
AK038994
AK085587
AL671894
BC099408
BC128494
BC128495
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GenPept |
AAH99408
AAI28495
AAI28496
BAC30196
BAC39480
CAM20609
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