Version 5.4
Mus musculus Protein: Acsm3
Summary
InnateDB Protein IDBP-268573.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Acsm3
Protein Name acyl-CoA synthetase medium-chain family member 3
Synonyms Sa; Sah;
Species Mus musculus
Ensembl Protein ENSMUSP00000102138
InnateDB Gene IDBG-208106 (Acsm3)
Protein Structure
UniProt Annotation
Function Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro). {ECO:0000269PubMed:11470804}.
Subcellular Localization Mitochondrion matrix {ECO:0000269PubMed:11470804, ECO:0000269PubMed:15525578}.
Disease Associations
Tissue Specificity Detected in kidney (at protein level). Detected in kidney proximal tubules and in liver. Detected at low levels in testis, stomach, heart and lung. {ECO:0000269PubMed:11470804, ECO:0000269PubMed:15525578, ECO:0000269PubMed:9449642, ECO:0000269PubMed:9507200}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0015645 fatty acid ligase activity
GO:0046872 metal ion binding
GO:0047760 butyrate-CoA ligase activity
Biological Process
GO:0006633 fatty acid biosynthetic process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:99538
InterPro IPR000873 AMP-dependent synthetase/ligase
PFAM PF00501
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3UNX5
PhosphoSite PhosphoSite-Q3UNX5
TrEMBL
UniProt Splice Variant
Entrez Gene 20216
UniGene Mm.334199
RefSeq NP_058566
MGI ID
MGI Symbol Acsm3
OMIM
CCDS CCDS21786
HPRD
IMGT
EMBL AB022340 AF068246 AK041060 AK143946 AK165516 AY064696 BC015248
GenPept AAC79656 AAH15248 AAL40880 BAA37141 BAC30805 BAE25622 BAE38232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca