Version 5.4
Mus musculus Protein: Dcun1d3
Summary
InnateDB Protein IDBP-268597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dcun1d3
Protein Name DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102129
InnateDB Gene IDBG-208255 (Dcun1d3)
Protein Structure
UniProt Annotation
Function Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8- conjugating E2 enzyme UBE2F. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0010225 response to UV-C
GO:0010332 response to gamma radiation
GO:0030308 negative regulation of cell growth
GO:0043065 positive regulation of apoptotic process
Cellular Component
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID MGI:2679003
InterPro IPR005176 Potentiating neddylation domain
PFAM PF03556
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K0V2
PhosphoSite PhosphoSite-
TrEMBL D3Z0Q3
UniProt Splice Variant
Entrez Gene 233805
UniGene Mm.472275
RefSeq
MGI ID
MGI Symbol Dcun1d3
OMIM
CCDS CCDS21789
HPRD
IMGT
EMBL AC122423 AC131702 AK029043 AK155160 BC030335
GenPept AAH30335 BAC26261 BAE33084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca