Version 5.4
| Mus musculus Protein: Cdc14a | |||||||||||
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| Summary | |||||||||||
| InnateDB Protein | IDBP-268655.6 | ||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
| Gene Symbol | Cdc14a | ||||||||||
| Protein Name | CDC14 cell division cycle 14 homolog A (S. cerevisiae) | ||||||||||
| Synonyms | |||||||||||
| Species | Mus musculus | ||||||||||
| Ensembl Protein | ENSMUSP00000102100 | ||||||||||
| InnateDB Gene | IDBG-189944 (Cdc14a) | ||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||
| Function | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis (By similarity). {ECO:0000250}. | ||||||||||
| Subcellular Localization | Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Centrosomal during interphase, released into the cytoplasm at the onset of mitosis. Subsequently localizes to the midzone of the mitotic spindle (By similarity). {ECO:0000250}. | ||||||||||
| Disease Associations | |||||||||||
| Tissue Specificity | |||||||||||
| Comments | |||||||||||
| Interactions | |||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||
| PDB ID | MGI:2442676 | ||||||||||
| InterPro |
IPR000242
Protein-tyrosine phosphatase, receptor/non-receptor type IPR000340 Dual specificity phosphatase, catalytic domain IPR000387 Protein-tyrosine/Dual specificity phosphatase IPR003595 Protein-tyrosine phosphatase, catalytic IPR020422 Dual specificity phosphatase, subgroup, catalytic domain IPR029021 Protein-tyrosine phosphatase-like |
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| PFAM |
PF00102
PF00782 |
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| PRINTS |
PR00700
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| PIRSF | |||||||||||
| SMART |
SM00194
SM00404 SM00195 |
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| TIGRFAMs | |||||||||||
| Post-translational Modifications | |||||||||||
| Modification | |||||||||||
| Cross-References | |||||||||||
| SwissProt | Q6GQT0 | ||||||||||
| PhosphoSite | PhosphoSite-Q6GQT0 | ||||||||||
| TrEMBL | |||||||||||
| UniProt Splice Variant | |||||||||||
| Entrez Gene | 229776 | ||||||||||
| UniGene | Mm.480133 | ||||||||||
| RefSeq | NP_001167024 | ||||||||||
| MGI ID | |||||||||||
| MGI Symbol | Cdc14a | ||||||||||
| OMIM | |||||||||||
| CCDS | CCDS51058 | ||||||||||
| HPRD | |||||||||||
| IMGT | |||||||||||
| EMBL | AK036556 BC072644 | ||||||||||
| GenPept | AAH72644 BAC29476 | ||||||||||