InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Toe1

Summary

InnateDB Protein

IDBP-268731.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Toe1

Protein Name

target of EGR1, member 1 (nuclear)

Synonyms

4930584N22Rik; 4933424D16Rik; AI413517;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102063

InnateDB Gene

IDBG-178754 (Toe1)

Protein Structure

UniProt Annotation

Function

Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Localizes to nuclear speckles. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0046872	metal ion binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:1915526

InterPro

IPR006941 Ribonuclease CAF1
IPR012337 Ribonuclease H-like domain

PFAM

PF04857

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D2E2

PhosphoSite

PhosphoSite-Q9D2E2

TrEMBL

UniProt Splice Variant

Entrez Gene

68276

UniGene

Mm.30534

RefSeq

MGI ID

MGI Symbol

Toe1

OMIM

CCDS

HPRD

IMGT

EMBL

AK016889 AK019829 AK046576 AK082975 AK148609 BC023109

GenPept

AAH23109 BAB30482 BAB31871 BAC32792 BAC38718 BAE28623