Version 5.4
Mus musculus Protein: Fbf1
Summary
InnateDB Protein IDBP-268770.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbf1
Protein Name Fas (TNFRSF6) binding factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000102043
InnateDB Gene IDBG-214414 (Fbf1)
Protein Structure
UniProt Annotation
Function Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:10978533}. Cell junction {ECO:0000250}. Note=Localizes specifically to the distal appendage region of the centriole, which anchors the mother centriole to the plasma membrane. Localizes to the apical junction complex (AJC) in epithelial cells (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Broadly expressed. {ECO:0000269PubMed:10978533}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0042384 cilium assembly
GO:0043297 apical junction assembly
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0000922 spindle pole
GO:0005814 centriole
GO:0043296 apical junction complex
GO:0045095 keratin filament
Protein Structure and Domains
PDB ID MGI:1922033
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2A870
PhosphoSite PhosphoSite-A2A870
TrEMBL Z4YLK3
UniProt Splice Variant
Entrez Gene 217335
UniGene
RefSeq XP_006533157
MGI ID
MGI Symbol Fbf1
OMIM
CCDS CCDS25659
HPRD
IMGT
EMBL AF241249 AK004058 AK031140 AL607108 BC055689 BC137794 BC144918
GenPept AAH55689 AAI37795 AAI44919 AAK28326 BAC25065 BAC27275 CAM24057 CAM24058

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca