Version 5.4
Mus musculus Protein: St3gal3
Summary
InnateDB Protein IDBP-268830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol St3gal3
Protein Name ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Synonyms Siat3; Siat6; ST3GalIII; ST3N;
Species Mus musculus
Ensembl Protein ENSMUSP00000102018
InnateDB Gene IDBG-180483 (St3gal3)
Protein Structure
UniProt Annotation
Function Catalyzes the formation of the NeuAc-alpha-2,3-Gal-beta- 1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- or NeuAc-alpha- 2,3-Gal-beta-1,3-GalNAc- sequences found in terminal carbohydrate groups of glycoproteins and glycolipids. The highest activity is toward Gal-beta-1,3-GlcNAc and the lowest toward Gal-beta-1,3- GalNAc.
Subcellular Localization Membrane; Single-pass type II membrane protein. Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Disease Associations
Tissue Specificity Found in all tissues tested. High expression found in brain, liver, kidney, colon, heart and spleen.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0097503 sialylation
Cellular Component
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID MGI:1316659
InterPro IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase
PFAM PF00777
PRINTS
PIRSF PIRSF005557
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97325
PhosphoSite PhosphoSite-P97325
TrEMBL B1AS81
UniProt Splice Variant
Entrez Gene 20441
UniGene Mm.411241
RefSeq NP_001155246
MGI ID
MGI Symbol St3gal3
OMIM
CCDS CCDS18544
HPRD
IMGT
EMBL AL611952 AL626764 AL627128 BC006710 CH466552 X84234
GenPept AAH06710 CAA59013 CAM14710 CAM26721 CAM27383 EDL30520 EDL30522

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca