InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tnrc6c

Summary

InnateDB Protein

IDBP-268957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnrc6c

Protein Name

trinucleotide repeat containing 6C

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101951

InnateDB Gene

IDBG-214570 (Tnrc6c)

Protein Structure

UniProt Annotation

Function

Plays a role in RNA-mediated gene silencing by micro- RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4- NOT and PAN deadenylase complexes (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003674	molecular_function
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0001706	endoderm formation
GO:0006417	regulation of translation
GO:0007492	endoderm development
GO:0031047	gene silencing by RNA
GO:0035162	embryonic hemopoiesis
GO:0048568	embryonic organ development
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0060964	regulation of gene silencing by miRNA
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2443265

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR019486 Argonaute hook domain

PFAM

PF00627
PF10427

PRINTS

PIRSF

SMART

SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3UHC0