InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gbp3

Summary

InnateDB Protein

IDBP-269224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gbp3

Protein Name

guanylate binding protein 3

Synonyms

AW228655; Gbp4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101828

InnateDB Gene

IDBG-197244 (Gbp3)

Protein Structure

UniProt Annotation

Function

Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation. {ECO:0000269PubMed:9659399}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9659399}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain, lung, heart, spleen, kidney, liver and intestine. {ECO:0000269PubMed:9659399}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	0
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0035458	cellular response to interferon-beta
GO:0042832	defense response to protozoan
GO:0044406	adhesion of symbiont to host
GO:0050830	defense response to Gram-positive bacterium
GO:0071346	cellular response to interferon-gamma

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol
GO:0020005	symbiont-containing vacuole membrane
GO:0031410	cytoplasmic vesicle

Protein Structure and Domains

PDB ID

MGI:1926263

InterPro

IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02841
PF02263

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61107

PhosphoSite