Version 5.4
Mus musculus Protein: Rhbdl2
Summary
InnateDB Protein IDBP-269259.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhbdl2
Protein Name rhomboid, veinlet-like 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000101810
InnateDB Gene IDBG-186316 (Rhbdl2)
Protein Structure
UniProt Annotation
Function Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity). {ECO:0000250}.
Subcellular Localization Rhomboid-related protein 2, C-terminal fragment: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3608413
InterPro IPR017213 Peptidase S54, rhomboid, metazoan
IPR022764 Peptidase S54, rhomboid domain
PFAM PF01694
PRINTS
PIRSF PIRSF037470
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2AGA4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 230726
UniGene
RefSeq XP_006503089
MGI ID
MGI Symbol Rhbdl2
OMIM
CCDS CCDS38873
HPRD
IMGT
EMBL AL683811
GenPept CAM19910

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca