InnateDB Protein
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IDBP-269352.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Zranb1
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Protein Name
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zinc finger, RAN-binding domain containing 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101763
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InnateDB Gene
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IDBG-211181 (Zranb1)
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Protein Structure
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Function |
Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'- linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Enriched in punctate localization in the cytoplasm. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:106441
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InterPro |
IPR001876
Zinc finger, RanBP2-type
IPR003323
Ovarian tumour, otubain
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PFAM |
PF00641
PF02338
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PRINTS |
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PIRSF |
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SMART |
SM00547
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TIGRFAMs |
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Modification |
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SwissProt |
Q7M760
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PhosphoSite |
PhosphoSite-Q7M760
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TrEMBL |
Q3USF2
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UniProt Splice Variant |
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Entrez Gene |
360216
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UniGene |
Mm.490863
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RefSeq |
XP_006508029
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MGI ID |
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MGI Symbol |
Zranb1
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OMIM |
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CCDS |
CCDS21929
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HPRD |
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IMGT |
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EMBL |
AC119806
AK140426
BN000126
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GenPept |
BAE24381
CAD67576
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