Version 5.4
Mus musculus Protein: Ssx2ip
Summary
InnateDB Protein IDBP-269362.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ssx2ip
Protein Name synovial sarcoma, X breakpoint 2 interacting protein
Synonyms Adip; AU014939; AU042321;
Species Mus musculus
Ensembl Protein ENSMUSP00000101757
InnateDB Gene IDBG-199101 (Ssx2ip)
Protein Structure
UniProt Annotation
Function Belongs to an adhesion system, which plays a role in the organization of homotypic, interneuronal and heterotypic cell-cell adherens junctions (AJs). May connect the nectin-afadin and E- cadherin-catenin system through alpha-actinin and may be involved in organization of the actin cytoskeleton at AJs through afadin and alpha-actinin. Acts as a centrosome maturation factor, probably by maintaining the integrity of the pericentriolar material and proper microtubule nucleation at mitotic spindle poles (By similarity). Involved in cell movement: localizes at the leading edge of moving cells in response to PDGF and is required for the formation of the leading edge and the promotion of cell movement, possibly via activation of Rac signaling. {ECO:0000250, ECO:0000269PubMed:12446711, ECO:0000269PubMed:22027834}.
Subcellular Localization Cell junction, adherens junction {ECO:0000269PubMed:12446711}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Note=Not found at cell-matrix AJs.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12446711}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0007155 cell adhesion
GO:0035020 regulation of Rac protein signal transduction
GO:0051297 centrosome organization
GO:2000145 regulation of cell motility
Cellular Component
GO:0005634 nucleus
GO:0005913 cell-cell adherens junction
GO:0031252 cell leading edge
GO:0034451 centriolar satellite
GO:0043234 protein complex
Protein Structure and Domains
PDB ID MGI:2139150
InterPro IPR021622 Afadin/alpha-actinin-binding
PFAM PF11559
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VC66
PhosphoSite PhosphoSite-Q8VC66
TrEMBL D3Z6T5
UniProt Splice Variant
Entrez Gene 99167
UniGene Mm.488685
RefSeq NP_001240698
MGI ID
MGI Symbol Ssx2ip
OMIM
CCDS CCDS57260
HPRD
IMGT
EMBL AC124987 AF532969 AK031356 AK043865 AK049080 BC021749 BC031527
GenPept AAH21749 AAH31527 AAO15015 BAC27363 BAC31684 BAC33536

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca