InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Foxk2

Summary

InnateDB Protein

IDBP-269443.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxk2

Protein Name

forkhead box K2

Synonyms

1110054H05Rik; 5730434B08Rik; 6230415M23Rik; ILF; Ilf1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101719

InnateDB Gene

IDBG-214971 (Foxk2)

Protein Structure

UniProt Annotation

Function

Recognizes the core sequence 5'-TAAACA-3'. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00089, ECO:0000269PubMed:16376864}.

Disease Associations

Tissue Specificity

Expressed in a wide range of adult brain regions, namely the piriform cortex, the major islands of Calleja and cells lining the lateral ventricles, the bed nucleus of stria terminalis, the paraventricular thalamic nucleus, habenula and all structures of the hippocampus. Also present in the hypothalamus, cerebral cortex and in the Purkinje cell layer in the cerebellum. Additionally expressed in dopamine neurons of the substantia and more sparsely in the ventral tegmental area. {ECO:0000269PubMed:16376864}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007389	pattern specification process
GO:0009888	tissue development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter