InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nlrp6

Summary

InnateDB Protein

IDBP-269582.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nlrp6

Protein Name

NLR family, pyrin domain containing 6

Synonyms

AI504961; Avr; Nalp6; Navr; Navr/Avr; Pypaf5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101660

InnateDB Gene

IDBG-211907 (Nlrp6)

Protein Structure

UniProt Annotation

Function

May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine- vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation. {ECO:0000269PubMed:21543645, ECO:0000269PubMed:21565393, ECO:0000269PubMed:21593405}.

Subcellular Localization

Isoform 1: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus membrane {ECO:0000250}.Isoform 2: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Predominantly expressed in the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in the small and large intestine, kidney and liver. {ECO:0000269PubMed:21543645, ECO:0000269PubMed:21593405}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding

Biological Process

GO:0009617	response to bacterium
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0042060	wound healing
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043409	negative regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0050727	regulation of inflammatory response
GO:0050777	negative regulation of immune response

Cellular Component

GO:0005575

cellular_component

Protein Structure and Domains

PDB ID

MGI:2141990

InterPro

IPR003590 Leucine-rich repeat, ribonuclease inhibitor subtype
IPR004020 DAPIN domain
IPR007111 NACHT nucleoside triphosphatase
IPR011029 Death-like domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02758

PRINTS

PIRSF

SMART

SM00368

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite