InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tinagl1

Summary

InnateDB Protein

IDBP-269688.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tinagl1

Protein Name

tubulointerstitial nephritis antigen-like 1

Synonyms

1110021J17Rik; Arg1; AZ-1; AZ1; Lcn7; TARP; Tinagl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101621

InnateDB Gene

IDBG-192515 (Tinagl1)

Protein Structure

UniProt Annotation

Function

May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein. {ECO:0000269PubMed:12600995}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in kidney, heart and adrenocortical cells of adrenal glands. Moderately expressed in spleen and liver. Also found in prostate, seminal vesicle, epididymis and testis in male reproductive organs. In adrenal glands is found in the outer cortical regions corresponding to the zona glomerulosa (zG) and the undifferentiated cell zone (zU) (at protein level). {ECO:0000269PubMed:11377975, ECO:0000269PubMed:12600995}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0008234	cysteine-type peptidase activity
GO:0030247	polysaccharide binding
GO:0043236	laminin binding