InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gmeb1

Summary

InnateDB Protein

IDBP-269797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gmeb1

Protein Name

glucocorticoid modulatory element binding protein 1

Synonyms

1110050A04Rik; AI256615; AI481278;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000101584

InnateDB Gene

IDBG-193716 (Gmeb1)

Protein Structure

UniProt Annotation

Function

Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm. Note=May be also cytoplasmic.

Disease Associations

Tissue Specificity

Ubiquitous. Low levels were detected in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0046872	metal ion binding