Version 5.4
Mus musculus Protein: Rcc1
Summary
InnateDB Protein IDBP-269809.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rcc1
Protein Name regulator of chromosome condensation 1
Synonyms 4931417M11Rik; AI326872; Chc1;
Species Mus musculus
Ensembl Protein ENSMUSP00000101571
InnateDB Gene IDBG-193857 (Rcc1)
Protein Structure
UniProt Annotation
Function Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo- cytoplasmic transport, mitosis and nuclear-envelope assembly (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Becomes dispersed throughout the cytoplasm during mitosis. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 55 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005087 Ran guanyl-nucleotide exchange factor activity
GO:0031492 nucleosomal DNA binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0032316 regulation of Ran GTPase activity
GO:0051225 spindle assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1913989
InterPro IPR000408 Regulator of chromosome condensation, RCC1
IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFAM PF00415
PRINTS PR00633
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VE37
PhosphoSite PhosphoSite-Q8VE37
TrEMBL A2CER2
UniProt Splice Variant
Entrez Gene 100088
UniGene Mm.408324
RefSeq
MGI ID
MGI Symbol Rcc1
OMIM
CCDS CCDS18723
HPRD
IMGT
EMBL AK150153 AL805897 BC019807 CR752656
GenPept AAH19807 BAE29345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca